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KMID : 0385920070180050406
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Journal of the Korean Society of Emergency Medicine
2007 Volume.18 No. 5 p.406 ~ p.413
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Relationships between β-fibrinogen gene -445 G/A Polymorphism, 448 G/A Polymorphism, and Plasma Fibrinogen Concentration in Korean Ischemic Stroke Patients
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Lee Jong-Seok
Ko Young-Gwan
Choi Han-Sung
Hong Hoon-Pyo
Cho Han-Jin
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Abstract
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Purpose: The aim of this study was to evaluate the β-fibrinogen gene -455 G/A and 448 G/A polymorphisms and to determine the relationship of these single nucleotide polymorphisms with plasma fibrinogen concentration and with the development of ischemic stroke in Korea.
Methods: 123 patients who were diagnosed with ischemic stroke at Kyung Hee University Hospital from March 2003 to February 2004 were compared to 230 control subjects. The genotypes of the β-fibrinogen gene -455 G/A and 448 G/A polymorphisms were confirmed by polymerase chain reaction (PCR), and the allele frequencies of the patient group were compared to those of the control group. The associations of the single nucleotide polymorphisms with development of ischemic stroke and risk factors of ischemic stroke were assessed.
Results: The patient group had more heterozygotes (G/A or A/G) in the β-fibrinogen gene than did the control group, and statistical analysis of the genotype frequencies indicated a significant difference between the patient group and the control group (p<0.05). The odds ratios of the allele frequencies were 1.53(95% CI; 1.03-2.29) for the -455 G/A polymorphism and 1.85(95% CI; 1.25-2.74) for the 448 G/A polymorphism, indicating a statistically significant difference between the patient and control groups. In ischemic stroke patients, the allele frequencies for smoking history and hyperfibrino-genemia yielded odds ratios of 1.96(95% CI; 1.17-3.27) and 2.40(95% CI; 1.31-4.40), respectively, for the -455 G/A polymorphism and 1.96(95% CI; 1.19-3.22) and 2.42(95% CI; 1.34-4.39) for the 448 G/A polymorphism.
Conclusion: The -455 G/A and 448 G/A single nucleotide polymorphisms of the β-fibrinogen gene appear to be associated with plasma fibrinogen concentration and the development of ischemic stroke in Korea.
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KEYWORD
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Stroke, Fibrinogen, Genetics, Single nucleotide polymorphism
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